New era of DNA sequencing and related bioinformatics

9 12 2011

I can say the passed week is a week full of great news.

Wednesday (Nov 30, 2011)
“DNA Sequencing Caught in Deluge of Data” — You must want to read this article.

Monday (Dec 5, 2011)
UK will invest £75M for a new BIOINFORMATICS HUB in current EBI, as part of the ELIXIR project. I guess this must be within the framework of the HORIZON 2020, which the EU’s new programme for research and innovation running from 2014 to 2020 with an €80 billion budget. €80 billion!! OMG!

Tuesday (Dec 6, 2011)
The National Human Genome Research Institute (NHGRI), as part of NIH, announced to invest $416 million on research of using genomic data for medical clinical research, including rare inherit disease. Three genome sequencing centers are funded, including the Broad Institute, Genome Institute at Washington University, and Human Genome Sequencing Center, Baylor College of Medicine.

Whole-genome sequencing seems becoming more and more popular since it’s becoming cheaper and faster. Citing what the ELIXIR website says, “Modern sequencers are capable of analysing the equivalent of a human genome every 14 minutes at a cost of US $5,000.” We cannot imagine how easy to get a personal genome sequenced in next 5 years.

So, next question is: What would you do if it became possible to sequence the equivalent of a full human genome for only $1,000? This is the Question of the Year of Nature in 2007, when the whole-genome sequencing is still quite expensive. Personally I like the Ewan’s answer there: Full employment in bioinformatics. Think about it: if you can get your genome sequence in $1, what would you do to that 3,000,000,000 DNA nucleotides?
First of all, you may want to store it (or maybe not, since it’s too large). There are already companied coming out to store the DNA data, like the startup recently invested by Google Ventures, DNAnexus. But question is: who really wants to store all 3G data file, even though the 3G USB just costs less than $1? To only store the difference (between a particular genome and some reference genome), instead of every bit, might be the final solution.
Next, you want to see/visualize it. “Viewing your genomic data on iPhone” is one of such bleeding topics. I am quite serious, Illumina is working on the project with Apple, and even there are working Apps out already.
The most informative thing next is to analysis the data. It’s also the most challenging one. People including myself are working hard on it (That’s why the Uncle Sam invest money on it). Let’s think about this in a non-academic way. More and more companies smell the big cake (first let’s assume it’s a big cake), for example the genotyping-phenotype company like 23andme, the bioinformatics company like GenomeRequest, and just yesterday I read news about a new company called Spiral Genetics (who collect the open source software to do bioinformatics for customers, in a very smart way). Last week, Nature News blog reports the OpenSNP, a website (maybe a company next month) designed by several undergraduate students from U. Washington, they try to build the website to let people share their personal genotype data (from 23andme, deCODEme etc.). It’s a very cool idea!

OK. I know some people might be still questioning whether we need whole-genome sequencing. For individual research, it’s true that not every case needs whole-genome sequencing. But like from old phone to iphone, or from iphone to iphone3G, 4G, 4Gs… do you really need to change your iphone to Iphone 4Gs? You may not, or I am sure practically you don’t need at all. I am still using my wife’s old Nokia, no touch-screen, but very practical. Then why iphone 4Gs are so popular? Because it’s the trend! The lower cost and human’s desire/curiosity/greediness makes it popular. So the same for personal genome sequencing data. The only thing is to show this in an elegant way that even your grandma can understand. That’s the business!

Advertisements




42 things that change when you have a baby

21 09 2011

What changes when you have a baby? A better question may be: What doesn’t change? Here, writer and mom Rebecca Woolf lists her most notable post-baby observations. Then scroll down to read our favorite comments from readers about how their babies changed their lives.

1. You finally stop to smell the roses, because your baby is in your arms.

2. Where you once believed you were fearless, you now find yourself afraid. [See a reader’s perspective in #22, below.]

3. The sacrifices you thought you made to have a child no longer seem like sacrifices.

4. You respect your body … finally.

5. You respect your parents and love them in a new way.

6. You find that your baby’s pain feels much worse than your own.

7. You believe once again in the things you believed in as a child.

8. You lose touch with the people in your life whom you should have banished years ago.

9. Your heart breaks much more easily.

10. You think of someone else 234,836,178,976 times a day.

11. Every day is a surprise.

12. Bodily functions are no longer repulsive. In fact, they please you. (Hooray for poop!)

13. You look at your baby in the mirror instead of yourself.

14. You become a morning person.

15. Your love becomes limitless, a superhuman power.
Read the rest of this entry »





《把话说到心坎里,把事做到点子上》

6 04 2010
目录:
前言
上篇:把话说到心坎里
一这样的话,请换方式说
哕唆的话,请精简了说 /3
责备的话,请换个方式说 /5
苦话,请裹上“糖衣”说 /6
正话,请从反面去说 /9
深奥的话,请类比着去说 /11
消极的话,请积极地说 /13

二这样的话,请主动去说
欣赏的话,请主动去说 /16
“硬话”,请理直气壮地说 /18
说不清的话,请用事实说 /20
讨价的话,请坚持去说 /22
驳斥的话,请以牙还牙说 /23

三这样的话,请温柔地说
鼓励的话,请耐心地说 /26
批评的话,请温和地说 /27
情话,请甜蜜地说 /29
命令之语,要请求着说 /31
宽恕的话,请体谅着说 /34

四这样的话,请委婉地说
劝服的话,请委婉地说 /37
伤人的话,请打圆场说 /39
良言忠告,请顺耳去说 /41
露骨的话,请隐藏点说 /43
纠错的话,要留面子说 /45
拒绝的话,请顾及情感说 /47

五这样的话,请幽默地说
自嘲的话,请幽默地说 /49
解围的话,请幽默点说 /51
交锋的话,请风趣地说 /53
还击的话,请幽默地说 /54
风趣的话,请分场合说 /56

六这样的话,请真诚地说
赞美的话,请真诚地说 /59
动人的话,请真诚地说 /61
道歉的话,请真诚地说 /63
请求之语,请礼貌地说 /65
辩论的话,请用情去说 /67

七这样的话,请谨慎地说
玩笑的话,请把握分寸说 /70
吹嘘的话,请谦逊地说 /72
多嘴的话,请最好少说 /74
两难的话,请含糊其辞说 /76
诱导的话,请旁敲侧击说 /78

八这样的话,请机智地说
应变的话,请机智地说 /80
说错的话,请借题发挥说 /82
圆谎的话,请巧妙去说 /83

激将的话,请抓逆反心理说 /85
对不礼貌问话,请含沙射影回答 /87

九这样的话,请适时再说
圆场的话,请及时去说 /90
感谢的话,、请快点去说 /92
奉承的话,请把握好时机说 /93
悬念的话,请停顿着说 /95
插嘴的话,请等时机再说 /98

十这样的话,请坚决不说
争执的话,请避免去说 /lOl
忌讳的话,请坚决不说 /103
隐私的话,请千万别说 /105
骗人的话,请千万别说 /107
自以为是的话,请切记不说 /109
扫兴的话,请最好不说 /111

下篇:把事做到点子上
一这样的事,请重点去做
难做的事,先从容易处去做 /117
摸准信息的事,有的放矢地去做 /119
繁杂的事,抓住关键点去做 /121
重要的事,放在前面去做 /124
感兴趣的事,要集中精力去做 /127

二这样的事,请积极去做
为老板分忧的事,要主动去做 /130
困难的事,满怀信心去做 /132
认准的事,排除嘲讽去做 /134
出人头地的事,要辛勤去做 /138

三这样的事,请及时去做
今天的事,不要等到明天去做 /140
已经决定的事,快速去做 /142
想好的事,要果断去做 /145
当机立断的事,毫不犹豫地去做 /146
选准目标的事,抓紧时间去做 /148

四这样的事,请灵活去做
危急的事,要冷静去做 /151
意外的事,要敏捷去做 /153
碰钉子的事,要绕个弯去做 /155
僵持的事,先退一步再做 /157

五这样的事,请借力去做
晋升的事,要借梯去做 /160
不懂的事,借他人智慧去做 /162
不必亲为的事,放手他人去做 /165

六这样的事,要有分寸地做
得理的事,不妨让几分去做 /169
不是本职的事,别越位去做 /172
承诺别人的事,要留有余地去做 /174
做不到的事,就退一步不做 /176

七这样的事,请小心去做
过热的事,要凉下来再做 /179
出风头的事,要低调去做 /182
功高盖主的事,要谦让着去做 /185
冒险的事,要谨慎去做 /188
容易冲突的事,平心静气去做 /190

八这样的事,请看透去做
约定俗成的事,不要打破规则去做 /192
别人忽略的事,要钻空子去做 /195
突发事件,要冷静地去做 /197
看不准的事,要静观其变再去做 /200

九这样的事,请坚持去做
梦想的事,要有信心去做 /202
绝望的事,不能轻言放弃 /203
吃亏的事,要忍住性子做 /206
利己的事,放长线去做 /208

十这样的事,请千万别做
斤斤计较的事,千万别做 /210
不留余地的事,千万别做 /213
急功近利的事,千万别做 /215
半途而废的事,千万别做 /217
……





书摘:驾驭细节才能走向成功

17 10 2008
今天,细节决定成败已成国人的共识。细节为什么能决定成败?细节能否超前发现,就像天气预报一样被提前感知?细节能否创造?创造细节有什么方法?如此这些,细节成了研究的新课题—— 

  从潜在的需求上发现细节 海尔造出可洗地瓜的洗衣机 

  在生活中,满足一个潜在需求,就能得到一个平步青云的机会;而在商海中,满足一个潜在需求,就带来滚滚财源。海尔的做法,值得我们深思。 

  这是一个大家都熟知的小故事。 

  1996年,一位四川农民投诉海尔洗衣机排水管老是被堵,服务人员上门维修时才发现,这位农民用洗衣机洗地瓜,泥沙大,当然容易堵塞。服务人员加粗了排水管。顾客感激之余,埋怨自己给海尔添了麻烦,说如果能有洗红薯的洗衣机,就不用烦劳海尔人员了。 

  这个信息令张瑞敏萌生了一个大胆的想法:发明一种洗红薯的洗衣机。 

  1998年4月,这种洗衣机投入批量生产。它不仅具有一般双桶洗衣机的全部功能,还可以洗地瓜、水果甚至蛤蜊,价格也低。首产1万台投放农村市场后,立刻被抢购一空。 

  这个细节告诉我们:产品创新必须与日常生活紧密结合。用户在日常生活中的不满意点、遗憾点及希望点,就是市场潜在的需求点。据此开发出的新产品,一定会受到用户的欢迎。 

  正如张瑞敏所说:“创新存在于企业的每一个细节之中。”农民投诉洗衣机被堵的细节,为海尔创新指明了方向。解决这个问题,就是创新的成果。 

  推而广之,日常生活中每个缺陷、每个有待完善的细节,都是产品创新的源泉。 

  从经济的变化中发现细节 日方在谈判桌上大获全胜 

  看了这则细节案例,你会由衷地感叹日本人的聪明。他们把这种聪明用来对付一切跟他们竞争的对手。这种聪明是怎样展示出来的呢? 

  大庆油田是我国最大的油田。但是,最早在开采油田的时候,除了中央领导和在工地上的工人,没有人知道关于大庆的任何资料。但是精明的日本人却知道了,他们从公开报道的蛛丝马迹之中“看”出了眉目,还从中获益。 

  《人民画报》上刊登了铁人王进喜身穿大棉袄、背景飘雪花的照片。日本人推断,大庆在中国东北。因为那个时候,只有东北在下雪。其后,日本人又根据运原油的列车上灰层的厚度,测出油田与北京的距离,认定油田应在哈尔滨与齐齐哈尔之间。 

  《人民日报》报道王进喜到了马家窑,大喊一声:“好大的油田啊!”日本人推断,马家窑是大庆的中心部位。 

  《人民日报》又报道了大庆人发扬“一不怕苦,二不怕死”的革命精神,肩扛人抬各种设备。日本人由此推断,大庆附近有铁路、公路,否则,人怎么可能长距离扛得动几千斤重的设备!于是,他们推断,大庆在安达车站附近。 

  1966年,王进喜作为人民代表参加了全国人民代表大会。日本人推断,大庆出油了! 

  《人民日报》刊登的一幅石油钻塔的照片,日本人看了以后,测算出了油井的直径,并据此测算出这台油井的产量。 

  《政府工作报告》公布了一些大庆的资料,日本人又测算出大庆油田的生产规模与产量。紧接着,日本人就设计生产了完全符合大庆油田的石油设备。当
中国刚一公布在国际上招标购买石油设备的时候,其他国家还没有来得及设计,日本人就把图纸给了中方。很快,他们就同中方签订了合同。这份合同让日本人受益
匪浅。 

  据事后有关方面透露,当时来跟中国洽谈进口石油设备的除了日本,还有美国、德国等大公司。他们曾向中东的伊朗、伊拉克和科威特都出售过石油设
备。但他们的设备,都是按照在非洲、在中东这样的酷热气候中的参数设定的,根本就不适合在大庆这样的严寒地区使用。即使要修改,一下子也来不及。因此,在
第一轮的设备的使用性能上,它们就被淘汰出局了。而日本人的设备,完全是按照大庆这样的严寒地区的需要设计的。加之要求投产的时间很急,即使日本人的价格
贵一点,也不得不买。这实际上就是日本人的绝招。 

  真正聪明的人能从“蛛丝马迹”中发现机会,而有的人却在那里空等机会。 

  把握细节,就把握机遇。问题在于,你能否超前发现细节,进而捕捉细节、掌控细节,让细节为你所用。 

  从重大的发明和发现中捕捉细节 格兰仕微波炉以低价取胜 

  微波炉是西方的一项重大发明,因其方便快捷而成为西方人生活的一种时尚。在改革开放的中国的今天,格兰仕公司断然采取多项有效措施,使微波炉在中国迅速普及,从而演绎了一个从重大的发明和发现中捕捉细节与商机的东方神话。 

  30年前,许多企业认为中国做不了微波炉,因为中国人消费不起,微波炉也不适合中国人的生活方式。 

  但是,格兰仕却认准了微波炉在中国的潜力。他们依据中国人的生活需要,把微波炉的功能单一化,只保留定“热”的功能,使生产成本大大降低,价格也比进口的品牌低许多。 

  进入市场并小有名气后,他们又掌握了微波晶体管这一重要技术。从此不需要进口微波管,实现了产品国产化。这样,价格再次大幅降低。质优价廉,比进口有更大的竞争优势。 

  有人算了一笔账:同样是赚1亿元,如果把产量从10万台上升到100万台,每台的利润就从1000元降到100元。这样,每台就是要赚1000
元的厂家就在这批价格战中死掉了。格兰仕就这样在竞争中站稳了脚,并且不花一分钱,只用无形资产和管理技术入股,先后兼并了六家生产微波炉的企业。他们只
向这些企业调派干部和技术人员,并没有动用资金。 

  中国微波炉市场的旗舰地位树立起来之后,格兰仕又将每台利润降到10元。这样,日本、韩国的微波炉就没有市场了。现在,格兰仕占有了中国大部分市场份额,它的价格也稳定了。 

  实践证明,格兰仕的思路是正确的。每一步胜利,都与其价格优势分不开。简化功能,掌握核心技术,形成生产规模,实现降价这一目的,终于取得了对日、韩微波炉战的决定性的胜利。而每一步的胜利,都是一个一个细节的成功实施的结果。 

  在平凡事物中创造细节 沃尔玛崛起的奥秘 

  在企业界,用不着法西斯式的训练方式。但是,培训自己的员工在市场上的执行力,同样是企业界不可或缺的。问题是怎样去培养。山姆·沃尔顿为什么会成气候?其成功的奥秘在哪里? 

  山姆·沃尔顿创业伊始,即抱定“以农村包围城市”的雄心,要一个州一个州、一个县一个县地把美国市场填满。 

  沃尔玛一直坚持顾客永远第一、“保证满意”的宗旨。一台果汁机出了点小毛病,营业员会立刻给顾客另换一台,还告诉用户:果汁机又降价了,我们还要退给你5美元。 

  沃尔玛的竞争对手斯特林商店开始采用金属货架,以代替木制货架后,沃尔玛立刻制作了更漂亮的金属货架,并成为全美第一家百分之百使用金属货架的杂货店。 
  沃尔玛认真记录分析每一个商业数据,运用通讯卫星控制物流,为每一个顾客服务。沃尔玛全球4000多个店铺都装有卫星接收器,把每一个消费者在其任何一个连锁店进行的交易的详细信息都“记录在案”,并送进企业信息动态分析系统,以便改进服务。

 沃尔玛视服务为生命,它要求任何一个职员,在顾客距自己3米以内一定要露出8颗牙齿微笑进行问候;顾客的任何要求,必须在太阳落山之前得到答复。 

  为了做到零成本促销,沃尔玛想方设法节约每一美分。 

  员工要喝咖啡,必须掏出10美分投进旁边的储钱罐里。 

  沃尔玛没有专用的复写纸,用的都是报告纸的背面;除非重要文件,沃尔玛都不用专业打印纸。其工作记录本,都是用废报告纸裁成的。 

  无论是总裁,还是经理,繁忙时都是店员。 

  沃尔玛少有大广告,广告的模特不是自家店员,就是员工的子女,这样就可以节省大量的广告费。 

  沃尔玛员工出差,很少住高级宾馆。山姆·沃尔顿外出,也经常与别人同住一个房间。沃尔玛不遗余力地降低采购成本,并监督全球工厂的每款产品的质量和价格。这使得沃尔玛的商品零售价格永远比竞争对手低3.8%。 

  2002年,沃尔玛结束了与外部采购组织的合作,自己雇用了数百名员工进行采购,并在全球建立了21家办公室,以加强监督。 

  如此变本加厉地节约为了什么?山姆·沃尔顿说:“为顾客省钱。” 

  正因为沃尔玛“外松内紧”、“克己让人”,才能在全球零售业中长盛不衰,笑傲群雄。 

  其实,沃尔玛之所以笑傲群雄,还有一个重要原因,就是它具有世界一流水平的现代化的物流。 

  其重要的特点是它在物流的过程中,所有的物品都不落地。 

  比如,沃尔玛卖饼干。从采购小麦起,到饼干上零售货架,自始至终都不落地。从市场上买来小麦,进了工厂,不是进仓库保管,而是直接进生产线,磨
成面粉。面粉不是进仓库,而是直接上饼干生产线,与糖等原料一起,制成饼干。饼干不是进仓库,而是上货车,直接运进商店。进商店不是进仓库,而是直接上货
架。为什么?原来他们没有仓库。 

  物流的全过程,组织得这样有水平,是世界上少有的。这一“杀手锏”,使得沃尔玛的采购成本,永远都比竞争对手低一大截。这就是沃尔玛卖东西永远比它的竞争对手便宜的重要原因之一。 

  山姆·沃尔顿说过:“如果你热爱工作,你每天就会尽自己的能力去追求完美,而不久你周围的每一个人,也会从你这里感染这种热情。” 

  凭着这种一丝不苟、追求完美的精神,凭着这种责任感、认真劲,山姆·沃尔顿开创的沃尔玛于20世纪60年代从美国阿肯色州的小城崛起,经过40多年的搏杀,眼下其商店总数已达4000多家,年收入2400多亿美元,列全球500强之首。 

  沃尔玛崛起的奥秘,其实就是一个一个成功实施的细节垒起来的。 

  摘自《细节案例》马金山 马文婷 李玉平著 人民日报出版社2008年4月版29.80元





The 10 Most Dangerous Mistakes YOU Probably Make With Women

17 04 2008

 

Here Are The Top Ten Reasons Why Men Fail With Women—And How To Make Sure YOU Avoid Every One Of These Deadly Common Mistakes…

-By David DeAngelo, Author Of “Double Your Dating”

MISTAKE #1: Being Too Much Of A “Nice Guy”

Have you ever noticed that the really attractive women never seem to be attracted "nice" guys?

Of course you have.

Just like me, I’m sure you’ve had attractive female friends that always seemed to date "jerks"… but for some reason they were never romantically interested in YOU.

What’s going on here?

It’s actually very simple…

Women don’t base their choices of men on how "nice" a guy is. They choose the men they do because they feel a powerful GUT LEVEL ATTRACTION for them.

And guess what?

Being nice doesn’t make a woman FEEL that powerful ATTRACTION.

And being NICE doesn’t make a woman CHOOSE you.

I realize that this doesn’t make a lot of logical sense, and it’s hard to ACCEPT… but GET OVER IT.

Until you accept this FACT and begin to act on it, you’ll NEVER have the success with women that you want.

MISTAKE #2: Trying To “Convince Her To Like You"

What do most guys do when they meet a woman that they REALLY like… but she’s just not interested?

Right! They try to "convince" the woman to feel differently.

Well, I have news for you… YOU WILL NEVER CHANGE HOW A WOMAN "FEELS" WHEN IT COMES TO ATTRACTION!

Never, ever, EVER.

You cannot CONVINCE a woman to feel differently about you with "logic and reasoning".

Think about it.

If a woman doesn’t "feel it" for you, how in the world do you expect to change that FEELING by being "reasonable" with her?

But we all do it.

When a woman just isn’t interested, we beg, plead, chase, and do our best to change her mind.

Bad idea. One that will never work.

MISTAKE #3: Looking To Her For Approval Or Permission

In our desire to please women (which we mistakenly think will make them like us), us guys are always doing things to get a woman’s "approval" or "permission".

Another HORRIBLE idea.

Women are NEVER attracted to the types of men who kiss up to them… EVER.

Don’t get me wrong here.

You don’t have to treat women BADLY for them to like you.

But if you think that treating a woman well means "always getting her approval and permission for things", think again.

You will never succeed by looking for approval. Women actually get ANNOYED at men who seek their approval.

Doubt me? Just ask any attractive woman if Wussy guys who chase her around and want her approval annoy her…

MISTAKE #4: Trying To “Buy” Her Affection With Food And Gifts

How many times have you taken a woman out to a nice dinner, bought her gifts and flowers, and had her REJECT you for someone who didn’t treat her even HALF as well as you did?

If you’re like me, then you’ve had it happen a LOT.

Well guess what?

It’s only NATURAL when this happens…

That’s right, I said NATURAL.

When you do these things, you send a clear message:

"I don’t think you’ll like me for who I am, so I’m going to try to buy your attention and affection".

Your good intentions usually come across to women as over-compensation for insecurity, and weak attempts at manipulation. That’s right, I said that women see this as MANIPULATION.

MISTAKE #5: Sharing “How You Feel” Too Early In The Relationship With Her

Another huge and unfortunate mistake that most men make with women is sharing how they "feel" too early on.

Attractive women are rare.

And they get a LOT of attention from men.

Most men don’t realize this, but attractive women are being approached in one way or another ALL THE

An attractive woman is often approached several times a DAY by men who are interested. This translate into dozens of times per week, and often HUNDREDS of times per month.

And guess what?

Attractive women have usually dated a LOT of men.

That’s right. They have EXPERIENCE.

They know what to expect.

And one thing that turns an attractive women off and sends her running away faster than just about anything is a guy who starts saying "You know, I really, REALLY like you" after one or two dates.

This signals to the woman that you’re just like all the other guys who fall for her too fast… and can’t control themselves.

Don’t do it. Lean back. Relax.

There’s a much better way…

MISTAKE #6: Not “Getting” How Attraction Works For Women

Women are VERY different from men when it comes to ATTRACTION.

You need to accept this fact, and deal with it.

When a man sees a beautiful, young, sexy woman, he INSTANTLY feels a sexual attraction.

But does the same apply for women?

Do women feel sexual attraction to men based mostly on looks? Or is something else going on?

Well, after studying this topic for over five full years now, I can tell you that women usually have their "attraction mechanisms" triggered by things OTHER than looks.

Have you ever noticed that you see a lot more average and unattractive men with beautiful women than the other way around?

Think about it.

Women are more attracted to certain qualities in men… and they’re attracted to the way a man makes them FEEL than they are to looks alone.

If you know how to use your body language and communication correctly, you can make women feel the same kind of powerful sexual attraction to you that YOU feel when you see a hot, sexy young woman.

But it’s not an accident. You have to LEARN how to do this.

And ANY guy can learn how…

MISTAKE #7: Thinking That It Takes Money And Looks

One of the most common mistakes that guys make is giving up before they’ve even gotten started… because they think that attractive women are only interested in men who have looks and money… or guys who are a certain height… or guys who are a certain age.

And sure, there are some women who are only interested in these things.

But MOST women are far more interested in a man’s personality than his wallet or his looks.

There are personality traits that attract women like a magnet…

And if you learn what they are and how to use them, YOU can be one of these guys.

YOU DO NOT have to "settle" for a woman just because you aren’t rich, tall, or handsome.

Let me say this again: If you know how to use your body language and communication correctly, you can make women feel the same kind of powerful sexual attraction to you that YOU feel when you see a hot, sexy young woman.

MISTAKE #8: Giving Away All Of Your Power To Women

Earlier I mentioned that it’s a mistake to look to a woman for approval or permission.

Well, another similar tactic that a lot of guys use is GIVING AWAY THEIR POWER to women.

Said differently, guys try to get women to like them by doing whatever the woman wants.

Another bad idea…

Women are NEVER attracted to men that they can walk all over… Women aren’t attracted to Wussies!

MISTAKE #9: Not Knowing EXACTLY What To Do In Each Type Of Situation With Women

Now I’m going to blow your mind…

A woman ALWAYS knows what you’re thinking.

Women are approximately TEN TIMES better than men at reading body language. That’s ten TIMES.

I know, it might be hard to believe. But for example, if you’re out on a date with a woman, and you want to kiss her, she knows it.

And if you don’t know exactly what to do and exactly HOW to kiss her, and you just sit there looking at her and getting nervous, she won’t help!

And this goes for ALL aspects of women and dating…

Approaching a woman, getting her number, asking her out, kissing her, getting physical… everything.

If you don’t know what to do in each situation, you will probably screw it up… and LOSE EVERYTHING.

And you KNOW it.

It is VITALLY important that you know EXACTLY how to go from one step to the next with a woman… from the first meeting, all the way to the bedroom.

MISTAKE #10: Not Getting HELP

This is the biggest mistake of all.

This is the mistake that keeps most men from EVER having the kind of success with women that they truly want.

I know, guys don’t like to make themselves look weak or helpless. We don’t like to ask for help.

Hey, I’ve been there myself.

Let me tell you a little about me and how I figured out how to be successful with women…

About five years ago I became fed up with the fact that I didn’t know how to approach, meet, and get dates with women that I was attracted to.

It frustrated the hell out of me.

One night I was out with a friend, and I saw a woman I wanted to ask out, but I just couldn’t get up the nerve to do it. I can still remember that night… right on the spot I made the decision to do whatever it took to learn how to be successful with women and dating.

Well, after a lot of hard work and trying all kinds of crazy things, I finally figured it all out.

I can now approach just about any woman and get her number almost instantly. I’ve dated models, I’ve dated actresses, and I’ve dated nice, normal, regular girls as well.

It has been a very rewarding experience. I no longer feel that sick, insecure feeling… like I don’t know how to meet women… and I might wind up alone.

I know that anytime, anywhere, I can go out and meet attractive women.

I’ve written a book on the topic, and I’ve done seminars on both coasts of the United States… and taught tens of thousands of men all around the world.

I Now Have A FREE, Three-Times-A-Week Email Newsletter…

…But the REALLY GREAT news is that I now publish a free email newsletter three times a week that teaches any guy how to increase his success with women DRAMATICALLY.

And I’d like to invite you to sign up.

It’s free, there’s no obligation, I’ll never share your email address with anyone, and you can easily remove yourself anytime with no hassles (and no, I’ll never pull any of these tricks where I send you a bunch of unwanted junk email when you try to remove yourself).

Of course, it even get’s better than that…

In addition to my free email newsletter, I also have a killer downloadable eBook that you can download right now and be reading in literally MINUTES from right now.

It’s JAM PACKED with dozens and dozens of specific strategies for overcoming fear, approaching women, getting phone numbers and email address from women quickly, great inexpensive or even free date ideas, and how to take things to a "physical" level smoothly and easily.

To sign up for my free three-times-a-week newsletter AND download your copy of this online eBook, just go here:

Free Newsletter And Download eBook

Oh, And One More Thing…

In this day and age of "instant gratification", I realize that this might just sound like another late-night info-mercial promising to make you rich by next week.

Well, that’s not the case.

I’ve spent a lot of time, effort, and energy writing this eBook. I wanted to design and create a program that ANY guy could easily understand and start using IMMEDIATELY to meet and date more women… without having to lie, do dishonest things, or be "manipulative".

I now believe that ANY man can be more successful with women and dating, and I get emails every day with success stories from guys who are using this program to meet and date wonderful women.

I know, I know… an ebook that can teach a regular guy how to be more successful in the dating world? No way.

Well believe me, this program will DRAMATICALLY increase your success with women… I absolutely guarantee it 100%.

If you’d like to take your success with women and dating to the next level, and have the kind of success that you’ve always wanted, then go sign up for my free newsletter, get all the details, and check out some great free samples of the eBook located here:

Free Newsletter And Download eBook

And I’ll talk to you again soon.

Your Friend,


David DeAngelo

P.S. Do some friends a favor, and FORWARD this article to their email addresses. It might be the biggest gift you ever give them.

_____________________________________________________________
Copyright 2008 David DeAngelo Communications Inc., All Rights Reserved. David DeAngelo and Double Your Dating are trademarks of David DeAngelo Communications Inc.

Link: http://www.flirtadvice.com/33/ten-mistakes.html





思君令人老

23 02 2008

  有时候,爱是坚韧的东西。可是有时候,它只是一池碧水,一榭春花,一陌杨柳,一窗月光,天明了,就要干涸,萎谢,褪色,消失。

  短暂到,不能用手指写完,等——待。

  思君使人老呵,百年修得同船渡,可是,还要千世才可修到共枕眠。突然,没有欲望再等待了。

  就让轩车来迟吧。爱的错手,只是个瞬间。然后我们黯淡下去,在彼此的眼底看见沉沦。

  可是,我看见你来,我问“轩车来何迟”时忍不住仍是淡淡的惊喜。你没有来迟,对不对?

  有一个人,你来了,就好了。

  遇上那个人时——似露珠在花叶上,轻轻颤抖的喜悦卑微。这样的轻佻,我们,无人幸免。

读安忆如的文字,突然觉得我们这样长距离的恋着未尝不是一种难得的幸福,没有距离哪来的思念,不是吗?





让我看着你

16 12 2007
从母亲住进我们医院的那一刻起,我就后悔自己当初选择的职业了。在外人的眼里,穿上那身洁白的衣服,我们这些做医生的就成了最美丽动人的天使,手中握有病
人的生死大权。可面对越来越消瘦的母亲,我除了一次又一次地走近她的身边,强颜欢笑地安慰着她,就只能偷偷躲到一个母亲看不到的角落抹眼泪。有那么多的患
者能在我的手上康复,母亲的病,却让我无能为力。

母亲是被我们硬逼着走进医院的,那个时候,她的癌细胞已扩散到整个胸部。整夜整夜的疼痛让她无法入睡,可她却从来不吱一声。每一次我进去看她的时候,她都
装作很平静的样子,面带微笑地看着我:“我觉得比先前好多了,你工作忙,不用老来看我。”握着母亲骨瘦如柴的双手,那一双曾经无数次爱抚过我的手,如今青
筋狂乱,布满了褐色的老年斑,我扭过头,去看挂在母亲头上方的吊瓶,有泪无声地掉落到心里。

母亲的生命进入倒计时,她也很清楚自己的时日不多了。大口大口地咳,把她鲜红的生命汁液一点点咳尽了。母亲每咳一次,我的心就被绞杀一次。我能为你做些什
么,哪怕能替你挨一个小时的疼痛,让你睡一个小时的安稳觉也好。可是,我什么也不能,白白地担着那家医院最好的外科主治医师的名誉。我丝毫没有办法留住母
亲。

午后的阳光照在洁白的病床上,我轻轻地梳理着母亲灰白的头发。母亲唠叨着她的身后事,她说她走后不要待在城市里,因为这里太吵了,她要找一个有山有水的地
方休息。她说她早在来之前就已准备好了自己的老衣,可惜还少了一条裙子,希望我们能尽快给她准备好。说这些的时候,母亲的脸上始终挂着平静祥和的笑。不像
是谈死,倒像去赴一个美丽的宴会。我的泪,再也忍不住,一滴又一滴地落到母亲的头发里。母亲爱美爱干净,一辈子都没有改变过。离开,都不忘记要体体面面地
去。

母亲的病房,离我的办公室仅有几步之遥,可她从来没有主动要求我去她的病房。每一次去,她还忙不迭地向外赶我,她说还有很多病人等着我,她嘱咐我一定要像
对待自己的家人那样对待病人。其实,我很清楚,每一次离开母亲的病房,身后那双依依不舍的眼睛会随着我的身影一直拐过屋角。我用分钟来计算着和母亲相守的
幸福,母亲却用秒钟来计算着能看到我的时光。有时候,她会硬撑着下床来,悄悄地站在我办公室的玻璃门外,静静地看着我。那是我几次偶然抬头时看到的。与我
的目光相遇,母亲马上像个孩子似的退回去,费力地转身回到病房了。母亲,在拼着最后的力气关注我。

那天与一位病人的家属争论,也许因为自己情绪太激动了,竟忘记了和我只有几步之遥的母亲。有一个年轻的女孩子急需眼角膜,恰巧医院里来了一位生命垂危的年
轻人,出于一个医者的责任,我劝那个年轻人的家长捐献出孩子的眼角膜。年轻人的父亲同意了,不想他的母亲却发疯般地找到我,说我根本不配做一个医生,也不
配做一个女人,因为我根本不懂得一位母亲的心。她说她决不允许谁动儿子一根毫毛,哪怕他不在这个世界了。我从医以来,什么样棘手的情况都经历过,却没遇到
过这么难办的事情。一边是女孩子的母亲苦苦哀求,一边是男孩的母亲拼命守护。最后,也许被我劝得急了,那位痛得发狂的母亲突然大声地说:“你觉悟高,怎么
不让你的家人来捐献?”我一下子呆在那里,顿时失声。是的,平心而论,我能那么做么?

母亲是何时出现在我的办公室门口的,我竟然一点都不知道。直到,听到那声熟悉的呼唤,抬起头,看见母亲正泪流满面地立在那里:“孩子,你看妈妈的眼角膜能
给那个孩子用么?”屋子里一下子静下来,几乎所有的目光都集中向了母亲。我几乎不敢相信,那话是从母亲嘴里说出来的。母亲最不能忍受的就是残缺,可她竟然
情愿让自己残缺着离开这个世界。看大家都在惊愕地盯着自己,母亲的脸上忽然现出少见的一点血色,她挣扎着走到我面前,静静地盯着我看了足足有一分钟,然
后,我听见母亲轻轻地在我面前说:“孩子,我想看着你,让我看着你!”

泪水狂涌而出,我第一次在自己的病人面前失态。我知道,那是母亲临走之前努力为我做的最后一件事。除却那份依依不舍的深情,她更不想让我为难。

后来,那个男孩的母亲含着泪同意了把儿子的眼角膜捐献给那个女孩,因为她觉得儿子的眼角膜毕竟比我母亲的要年轻。更重要的一点,她说,她也想让儿子的眼睛,一直看着她。从我母亲的身上,她明白:爱,原来可以用这样的方式延续。

——摘自《意林》2007年第11期 文/王焕伟