The tide: personal genome sequencing

14 10 2011

I cannot be more excited to share what I read today, all about the personal genome sequencing.

First let’s watch the TED talk by Richard Resnick, CEO of GenomeQuest.

Also, several related companies additional the well-known 23andMe:




Of course, I want to broadcast a blog, http://www.genomesunzipped.org/, written by a group of graduate students, postdoc, and professor etc. from different countries. They wrote very good quality blogs (including the one excited me today, about discussion the possible error in a recent Science paper), and more interesting is that they post their personal SNP data (from above companies) online and you can download and browse the data. Cool?

Ending with what Rick said in his TED talk, “And at the time — this was a few years ago — it cost $100,000. Today it’s $10,000. Next year it’s $1,000. The year after it’s $100, give or take a year. That’s how fast this is moving.” Exactly, that’s how fast this is moving! How about us? and how about me?

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listening

15 08 2011

I got this piece of text from a TED conversation. Just think it’s helpful and so necessary for me to learn:

Effective Communication Skills … needed for life at every possible level!

Such skills are essential for personal, work, right up to international relationships.

For me these would include:

> sincere, clear and concise but kind words – written and spoken;
>active listening, as in actually hearing what others say and clarifying to be very sure;
>ability to negotiate win-win outcomes for all, this often means a degree of ‘compromise’ for all parties;
>ability to reason logically, to collaborate and network with others

I believe that lack of such skills can complicate and often are responsible for conflict from arguments and divorce right up wars.
# Do you agree?

# What does ‘effective communication’ mean to you?

# What lies do you readily tell or believe in?

# Share a situation where lies or ineffective skills caused you grief?

RELATED TALKS:
Evelyn Glennie shows how to listen
Elif Shafak: The politics of fiction
Julian Treasure: 5 ways to listen better
Marco Tempest: The magic of truth and lies (and iPods)

From the 3rd talk, there are five exercises to improve conscious listening:
1. silence — use 5min a day of silence to reset your ears and to calibrate… make sense very much!
2. mixer — I prefer to say ‘distinguish’. Try to distinguish the channels of noise/sounds around you, even in a noisy environment.
3. savoring — try to enjoy/taste the choir in an even boring noise.
4. positioning — change position to listen different aspects of sound
5. RASA — an acronym stands for Receive, which means pay attention to the person; Appreciate, making little noises like hmm, oh, okay; Summarize, the word “so” is very important in communication; and Ask, ask questions afterward.





单克隆抗体

4 05 2010
单克隆抗体由可以制造某种单一抗体的免疫B淋巴细胞与骨髓瘤细胞融合后的细胞产生的,这种融合细胞即具有瘤细胞不断分裂的能力,又具有免疫细胞能产生抗体的能力。

1984年的诺贝尔生理学或医学奖颁发给这项技术的发明者:Niels K. Jerne(丹麦),Georges J.F. Köhler(德国),César Milstein(英国)。

// 凡事都是双刃剑,骨癌细胞也不是一无是处,关键是看怎么利用





Note

5 04 2010

Key researchers in molecular
evolution





继续学习进化

4 04 2010
总结一下最近学习进化的理解:

  • 进化是两种反力作用的结果:一方面不断地在性征中(trait,指DNA序列或者传统的形态特征)中引入变异,另一方面又使某些特定的变异在种群内得以保留或者剔除;
  • 基因DNA序列发生变异(variation)是因为突变(mutation)。突变发生的原因很多,例如辐射、病毒、化学物质的影响或者细胞分裂时遗传基因复制发生错误。
  • 主要有两个过程使得这些变异得以保留或者剔除:一个是自然选择(Natural Selection),就是"物竞天择“,达尔文大爷进化论的核心;另外一个就是遗传漂变(Genetic Drift),指一个等位基因可能在经过数代后因为随机选择的原因在一个族群中消失(下图就是一个例子,红球变没了)。自然选择强调自然,强调物种与环境的接触;而遗传漂变不强调自然,认为选择是随机发生的。遗传漂变对于小size的种群影响更大,人口瓶颈就容易产生遗传漂变,进而发生种族灭绝,或者多样性变单一。这两个过程被认为同时存在。





性,进化,红色皇后效应

2 04 2010
If environmental interactions include other rapidly evolving species,
then the pressure to change may never stop, and the evolutionary
optimum will always remain some steps ahead. Host-parasite interactions
are a famous example of this sort of situation. Here, the host immune
system evolves to recognize a special structure on the parasite and
allow its removal. This in turn induces negative selection on the current form of the parasite while
leading to positive
selection
of variants that cannot be recognized by the host.
Furthermore, if such variant parasites exist, they will increase in frequency
and in turn induce negative selection
of the current variant of the host, which will lead to the positive selection of hosts that can again recognize the
parasite, and so on. Negative (and positive) selection in such a system never rests, which is why one
hypothesis describing these systems was named after the Red Queen in the
book Alice in Wonderland, who famously stated that it takes a
great amount of running to stay in the same place. [Loewe, L. (2008) Negative selection. Nature Education 1(1).  http://www.nature.com/scitable/topicpage/Negative-Selection-1136%5D

// 我怎么不记得Alice in Wonderland中有这段?真想再看一遍

// 由此geek到一本想看的书:《红色皇后:性与人性的演化》(The Red Queen: Sex and the Evolution of Human Nature )。书摘中有一句话很有意思:“依数学模式而言,必须获得特奖,彩券模式才有意义:同理,必须多少有一些扩散者获得生存,而且表现良好,性才能获得报酬,否则性只是白费力气。”  嗯,获得生存,表现良好!





知识,智慧,和博闻强识

30 03 2010
  生活是一个小偷。
  它让你个子长高,知识增多以后,悄悄地偷走了你的童真;
  它让你能说会道,表情丰富之后,悄悄地偷走了你的好奇。
  它让你聪明,懂事了之后,悄悄地偷走了你的微笑;
  它让你走了许多路,过了许多桥之后,悄悄地偷走了你的勇气。

// 很有道理!以前上学的时候,有人在上面做报告,介绍到某个新知识,看到下面有个老师忙着往本子上记,心里就特别死小孩,想:这个我都会,亏你还老师呢,这个都不会!最近发现自己也是在别人做报告的时候忙不迭地记东西,生怕遗漏下什么……看到这句话的时候,就在想:是不是自己也老了?又为了不让自己落伍,只能手忙脚乱的拾捡别人的二手知识。当生活让我们学会一些东西之后,我们就失去了学习新东西的勇气和欲望了。不然,为什么跟很多年过30的人谈学习,都会说:哎呀,我已经过了读书的那个年龄了!

// 想到这里,第二个问题就出来了:为什么有些人年纪很大了,还会坚持学习,走在前面呢?譬如Boris,譬如zhiping Weng。我觉得这些人都是‘博闻强识’的类型,就是不仅知识面广,还记忆力好。大部分人年纪大了,就只有智慧,没有知识了。

// 上面那个书摘还有后面一部分,全文见此(http://www.dengb.com/article.asp?id=4210)。顺便推荐一下作者邓冰老师的主页,不错!