The tide: personal genome sequencing

14 10 2011

I cannot be more excited to share what I read today, all about the personal genome sequencing.

First let’s watch the TED talk by Richard Resnick, CEO of GenomeQuest.

Also, several related companies additional the well-known 23andMe:

Of course, I want to broadcast a blog,, written by a group of graduate students, postdoc, and professor etc. from different countries. They wrote very good quality blogs (including the one excited me today, about discussion the possible error in a recent Science paper), and more interesting is that they post their personal SNP data (from above companies) online and you can download and browse the data. Cool?

Ending with what Rick said in his TED talk, “And at the time — this was a few years ago — it cost $100,000. Today it’s $10,000. Next year it’s $1,000. The year after it’s $100, give or take a year. That’s how fast this is moving.” Exactly, that’s how fast this is moving! How about us? and how about me?



2 responses

18 10 2011

Just to comment myself:

There is a news on latest Nature Review Genetics,

demonstrating another example of personal genomic variant which could result in disease. But it’s more to say that the offspring with different inheritance of variant could benefit from lifestyle changes or preventative anticoagulants, and particular drugs that could result in adverse bleeding if combined.

They also highlight that “in genomic analyses, the quality of the reference can be as crucial as the samples themselves”. They made 3 different reference genomes according to different regions (African/Europe/Asia), by replacing ~1.6 million SNPs in Hg19 with the most common allele at each position in European, African and East Asian populations.

25 10 2011

Speaking at Singularity University on October 3, the chief scientist for Genomera explains that the genomics wave is quietly gathering force, piling up base pairs in exponentially growing databases that will crash on the shores of medicine with the disruptive force of a tidal wave.

McCauley’s parting advice to the students of the SU Executive Program: “Find an exponential trend and hitch-hike on it. Don’t be the guy who builds the sequencing machine that does a genome for a penny. Find useful ways to take advantage of that capability.” No one doubts that the one-cent genome is coming. Someone will turn it into a billion-dollar business. It’s an opportunity waiting to happen.

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